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3 edition of Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation found in the catalog.

Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation

Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation

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Published by Management and Technical Services Co., National Aeronautics and Space Administration, National Technical Information Service, distributor in [Houston, Tex.?], [Washington, D.C.?, Springfield, Va .
Written in English

    Subjects:
  • Calcium -- Metabolism -- Mathematical models,
  • Space flight -- Physiological effect -- Mathematical models

  • Edition Notes

    Other titlesSpace flight simulations of calcium metabolism using a mathematical model of calcium regulation
    StatementSusan N. Brand
    SeriesNASA contractor report -- NASA CR-171883
    ContributionsManagement and Technical Services Company, United States. National Aeronautics and Space Administration
    The Physical Object
    FormatMicroform
    Paginationiii, 32 p.
    Number of Pages32
    ID Numbers
    Open LibraryOL18007697M

      ABSTRACT. Dietary calcium plays a pivotal role in the regulation of energy metabolism because high-calcium diets attenuate adipocyte lipid accretion and weight gain during the overconsumption of an energy-dense diet and increase lipolysis and preserve thermogenesis during caloric restriction, which thereby markedly accelerates weight by:


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Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation Download PDF EPUB FB2

SUBJECT Space-Flight Simulations of Calcium Metabolism Using a Mathematical Model of Calcium Regulation Z4_ql _U ___u_ _ This report presents the results of a series of simulation studies of calcium _ mem_U metabolic changes which have been recorded duri,lg humanexposure to bed rest::_ mo and space Size: 1MB.

Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation Author: Susan N Brand ; Management and Technical Services Company. The bed rest and space flight simulations were executed on a mathematical model of the calcium metabolic system.

The purpose of the simulations is to theoretically test hypotheses and predict system responses which are occurring during given experimental : S. Brand. A mathematical model is proposed for human calci um metabolism. The bodily calcium content is divided into one homogeneous compartment containing plasma calcium, three homogeneous compartments exchanging with it and representing a part of the tissue and bone calcium, a series of homogeneous compartments representing calcium.

The calcium tracer studies included mathematical modeling of the calcium kinetics, which estimated a net bone calcium loss of about mg/d.

24 This fits very closely with the Skylab calcium balance data, which showed whole-body calcium losses of to mg/d. 1Cited by: Weightlessness induces bone loss. Understanding the nature of this loss and developing means to counteract it are significant challenges to potential human exploration missions.

This article reviews the existing information from studies of bone and calcium metabolism conducted during space by: Increased bone resorption and largely unchanged bone formation result in the loss of calcium and bone mineral during space flight, which alters the endocrine regulation of calcium metabolism.

2 Mathematical model This model seeks to describe calcium homeostasis. The components in the blood plasma are the calcium concentration Ca, parathyroid hormone P, and calcitriol C. The size of the parathyroid gland can change and we denote its size by G.

A schematic describing the Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation book between these components is found in Figure 3.

A mathematical model of calcium homeostasis is presented in which the controllingfactors are the plasma concentrations of calcium, PTH, and calcitriol, and theeffector organs are the parathyroids, bone, kidney, and intestine.

Other factors can be added as the need by:   Calcium ions enable cells to communicate with one another, allowing neurons to interact, muscles to contract, and the heart’s muscle cells to synchronize and beat.

To better understand these processes, in which calcium ions interact with biological molecules such as proteins, researchers often use computer simulations. Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation [microfo Calcium regulation by calcium antagonists / Ralf G.

Rahwan, editor ; Donald T. Witiak, editor; Molecular and cellular regulation of calcium and phosphate metabolism: proceedings of the Symposium on. CALCIUM BALANCE AND CALCIUM METABOLISM Negative calcium balance was observed during Skylabll,2 and Mir4 mISSIOns. Increased urinary and fecal calcium excretion accounted for most of the ,14,2S Increased calcium excretion is a major contributor to the increased risk of renal stone formation d~~_ 3?d after spa~ep~g~.

File Size: 5MB. The role of supplementary calcium in submaximal exercise and endurance performance. Rehana Jawadwala. A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at the University of Central Lancashire.

March Calcium Metabolism in Health and Disease Munro Peacock Indiana University Medical School, Indianapolis, Indiana This brief review focuses on calcium balance and homeostasis and their relationship to dietary calcium intake and calcium supplementation in healthy subjects and patients with chronic kidney disease and mineral bone disorders (CKD-MBD).File Size: KB.

The Minimal Model of Glucose Regulation: A Biography. Richard N. Bergman. Calcium Colon Glutamat Nutrition Simulation Vitamin A calculus cancer carbohydrate mathematical modeling metabolism model modeling statistical analysis tea.

Editors and affiliations. Calcium bound to albumin: Forms about 40% to 42% of plasma calcium. Calcium in Bones Calcium is constantly removed from bone and deposited in bone. Bone calcium is present in two forms: 1. Rapidly exchangeable calcium/exchangeable calcium which is available in small quantity in bone and helps to maintain the plasma calcium level 2.

We developed a mathematical model of calcium (Ca) and phosphate (PO4) homeostasis in the rat to elucidate the hormonal mechanisms that underlie the regulation of Ca and PO4 balance.

The model represents the exchanges of Ca and PO4 between the intestine, plasma, kidneys, bone, and the intracellular compartment, and the formation of Ca-PO4-fetuin-A by: 3.

Regulation of calcium metabolism can be con­ sidered from at least three distinct but interrelated aspects: (i) control of the concentration of calcium in extracellular fluid and tissues; (ii) control of the body'soverall calcium balance, i.e., the relationship between gains and losses; (iii) control ofthe shape.

Calcium metabolism and osteoporotic ridge resorption R. Blank, H. Diehl, G. Ballard, and R. Melendez (JPD NOV ) Osteoporosis may be defined simply as a condition of insufficient bone.

This deficiency undermines skeletal strength, resulting in fractures that occur with minimal stress in the spine, distal radius and ulna, and in. Bone Markers, Calcium Metabolism, and Calcium Kinetics During Extended-Duration Space Flight on the Mir Space Station Scott M Smith, 1 Meryl E Wastney, 2 Kimberly O O’Brien, 3 Boris V Morukov, 4 Irina M Larina, 4 Steven A Abrams, 5.

In this video, Dr Anshumaan Tripathi has discussed about the calcium metabolism concept, it's absorption, distribution and physiological functions. Mathematical simulation and analysis of cellular metabolism and regulation.

2,6-bisphosphatase from rat liver were simulated with a mathematical model proposed by the authors earlier and. Abstract. A mathematical model is proposed for human calcium metabolism. The bodily calcium content is divided into one homogeneous compartment containing plasma calcium, three homogeneous compartments exchanging with it and representing a part of the tissue and bone calcium, a series of homogeneous compartments representing calcium in the gastro-intestinal tract, and an un-mixed Author: John Hamilton Livesey.

Calcium and Cell Function, Volume V emphasizes the roles of calcium in cellular functions. This book consists of eight chapters. Chapter 1 presents evidence for the role of calmodulin in cell proliferation. The role of calcium in the control of cyclic AMP metabolism in glial and pituitary tumor cells is analyzed in Chapter Edition: 1.

Calcium Regulation in Birds CALCIUM Calcium exists as three fractions in the avian serum: 1) the ionized salt, 2) calcium bound to proteins, and 3) as complexed calcium bound to a variety of anions (citrate, bicarbonate and phosphate).

Ionized calcium is the physiologically active fraction of serum calcium. When we began to organize the workshop "Calcium and Cellular Metabolism: Transport and Regulation" the goal we had in mind was to put together the knowledge of 2 several specialists on Ca + homeostasis, with various examples of cellular metabolisms 2 2 (such Cited by: Abstract.

That calcium ions play a role in the regulation of cardiac contraction was realized by Sidney Ringer, who reported in that the presence of calcium ions in the extracellular fluid was necessary to maintain the beating of the isolated, perfused heart (1).Author: Niels Haugaard, Marilyn E.

Hess. Molecular Biology: Calcium and Cell Function, Volume VI deals with several topics relating to calcium and cell function. This book consists of nine chapters.

Chapter 1 describes the various peptides that recognize calmodulin in a calcium-dependent Edition: 1. of the calcium in the body exists as the mineral. hydroxyapatite, Ca. 10 (PO. 4) 6 (OH) 2. Calcium. in the plasma: 45% in ionized form (the physiologically active form) 45% bound to proteins (predominantly albumin) 10% complexed with anions (citrate, sulfate, phosphate) Both total calcium and ionized calcium measurements are available in many.

Bone Metabolism • Bone acts as a reservoir for calcium and phosphate • Bone remodeling allows for release and uptake of calcium – thus one control of bone remodeling is calcium level • Bone remodeling is a constant, not random process – always going on but. calcium metabolism before, during, and after long-duration spaceflight extends results from Skylab missions in the s.

Biochemical and endocrine indexes of calcium and bone metabolism were measured together with calcium ab-sorption, excretion, and bone turnover using stable isotopes.

Studies were conducted before, during, and after flight in. Long-time simulation of calcium flow in a cell of size byby um with a byby lattice of CRUs using a byby element mesh from time 0 ms to ms without any initial stimulation.

The simulations use the parameters and boundary conditions of the three-dimensional model as specified in Gobbert (). Calcium metabolism is the movement and regulation of calcium ions in and out of the body, and between body compartments: the blood plasma, the extracellular and intracellular fluids, and bone.

Bone acts as a calcium storage center for deposits and withdrawals as needed by the blood via continual bone remodeling.– An important aspect of calcium metabolism is plasma calcium homeostasis, the.

This chapter focuses on calcium in the context of dietary sources and providing bases of calcium metabolism in the human body. Calcium is an inorganic element essential to living cells present in the Earth's biosphere as a solid matter and aqueous solution.

In humans, calcium is an essential constituent of bones and teeth where it supports Cited by: 4. This brief review focuses on calcium balance and homeostasis and their relationship to dietary calcium intake and calcium supplementation in healthy subjects and patients with chronic kidney disease and mineral bone disorders (CKD-MBD).

Calcium balance refers to the state of the calcium body stores, primarily in bone, which are largely a function of dietary intake, intestinal absorption, renal Cited by: space light requirements, and to that end, the text of the Space Nutrition book included basics of nutrient metabolism and requirements on Earth, and much of the available data related to space light.

Because, to a degree, the format was thrust upon us, and the timeline was short, the book reads a little like an encyclopedia. Recent developments in our knowledge of cellular calcium metabolism are reviewed. Changes in the Ca 2+ concentration in the cell cytosol are a nearly universal means of coupling stimulus with response in both neural and endocrine cells.

In particular, Ca 2+ serves as an important intracellular messenger in the regulation of cardiac and smooth muscle function, the regulation of aldosterone Cited by: Plasma Calcium Concentration.

Calcium Balance. Calcium Absorption. Renal Handling of Calcium. Interpretation of urinary calcium excretion. Bone. Calcium Regulating Hormones. Parathyroid hormone. Vitamin D. Calcitonin. Summary of Response to Hypocalcaemia or Hypercalcaemia.

Other Hormones. Parathyroid Hormone Related Peptide (PTH-rP. Calcium metabolism is predominantly regulated by two hormones and one vitamin that closely interact with each other if there are changes in the blood calcium level.

The paired parathyroid glands (one or two pairs depending on species varieties) secrete parathyroid hormone in response to a lowered blood calcium level. Calcium and bone metabolism during space flight Until its deorbit inthe Mir space station provided a valuable platform for long-duration space missions and life sciences research.

Long-duration flights are critical for studying bone loss because the 2- to 3-wk Space Shuttle flights are not long enough to detect changes in bone mass. Get this from a library! Calcium and cell function.

[Wai Yiu Cheung;] -- Calcium and Cell Function, Volume I: Calmodulin covers calmodulin-regulated functions. The book discusses the preparation, properties, structure, function, evolution, and structure-function.Calcium metabolism and breast cancer risk Almquist, Martin Link to publication Citation for published version (APA): Almquist, M.

(). Calcium metabolism and breast cancer risk. Department of Clinical Sciences, Lund University. General rights Unless other specific re-use rights are stated the following general rights apply.Calcium ions (Ca 2+) contribute to the physiology and biochemistry of organisms play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in enzymes require calcium ions as a cofactor, including several of the coagulation factors.